Publications

Selected papers

Herrera, R., Alvarez, M.C., Gelis, S., Kodedova, M., Sychrova, H., Kschischo, M. and Ramos, J. Role of Saccharomyces cerevisiae Trk1 in stabilization of intracellular potassium content upon changes in external potassium levels
Biochimica et Biophysica Acta 1838 (2014) 127–133
Burrell, R.A., McClelland, S.E., Endesfelder, D., Groth, P., Weller, M.C., Shaikh, N. Rowan, Domingo, E., Kanu, N., Dewhurst, S.M., Gronroos, E., Rowan, A.J., Schenk, A., Sheffer, M., Howell, M., Kschischo, M., Behrens, A., Helleday, T., Bartek, J., Tom- linson, I.P. and Swanton, C. Replication stress links structural and numerical chromosomal instability in colorectal cancer.
Nature 494, 492-496, doi:10.1038/nature11935 (2013).
Lu, L., Teixeira, V.H., Yuan, Z., Graham, T.A., Endesfelder,D., Kolluri,K., Al-Juffali,N.,Hamilton, N.J., Nicholson, A., Falzon, M., Kschischo, M., Swanton, C., Wright, N.A.,Carroll, B., Watt, F.M., George, J., Jensen, K.B., Giangreco, A., Janes, S.M.LRIG1 regulates cadherin-dependent contact inhibition directing epithelial homeostasisand preinvasive squamous cell carcinoma development.
J Pathol. 2012 Dec 3. doi: 10.1002/path.4148. [Epub ahead of print]
Kahm, M., Navarrete, C., Llopis-Torregrosa, V., Herrera, R., Barreto, L., Yenush, L., Arinho, J., Ramos, J. and Kschischo, M. Potassium starvation in yeast: Mechanisms of homeostasis revealed by mathematical
modeling.
PLoS Comput Biol 8(6): e1002548. doi:10.1371/journal.pcbi.1002548 (2012).
Lee, A.J.X., Roylance, R. Sander, J., Gorman, P., Endesfelder, D., Kschischo, M., Jones, N.P. and East, P., Nicke, B., Spassieva, S., Obeid, L.M. and Birkbak, N.J. and Szallasi, Z., McKnight, N.C. and Rowan, A.J., Speirs, V., Hanby, A.M. Downward, J., Tooze, S.A. and Swanton, C. CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid-
specific cancer cell death through autophagy induction.
J Pathol. 226, 482-494, (2012).
Roylance, R., Endesfelder, D.,Gorman, P. A., Burrel, R., Sander, J., Well, I. , Hanby, A., Spiers, V.,Richardson, A., Birkbak, N. J., Eklund, A. C., Downward, J., Kschischo, M., Szallasi, Z. and Swanton, C. Relationship of Extreme Chromosomal Instability with Superior Long-term Survival in
a Retrospective Analysis of ER-Negative Primary Breast Cancer.
Cancer Epidemiol Biomarkers Prev July 22 (2011).
Endesfelder, D., McGranahan, N., Birkbak, N.J., Szallasi, Z., Kschischo, M., Graham, T. and Swanton, C. A breast cancer meta-analysis of two expression measures of chromosomal instability reveals a relationship with younger age at diagnosis and high risk histopathological variables.
Oncotarget 2, 529-537 (2011).
Lee, A.J., Endesfelder, D., Rowan, A.J., Walther, A., Birkbak, N.J., Futreal, A., Downward, J.,Szallasi, Z., Tomlinson, I.P., Howell, M., Kschischo, M. and Swanton, C. Chromosomal Instability Confers Intrinsic Multi-Drug Resistance.
Cancer Research 71, 1858-1870 (2011).
Paeth, H., Lindenberg, J., Kschischo, M. and Hense, A. How dynamic models can learn from the data - an example with a simplified ENSO model.
Theoretical and Applied Climatology, online first (2010).
Kschischo, M. A gentle introduction to the thermodynamics of biochemical stoichiometric networks in steady state.
Eur. Phys. J. Special Topics 187, 255-274 (2010).
Kahm, M., Hasenbrink, G., Lichtenberg-Frat ́ , H., Ludwig, J. and Kschischo, M. Grofit: Fitting biological growth curves with R.
Journal of Statistical Software, 33 (2010). URL http://www.jstatsoft.org/v33/i07.
Swanton, C., Nicke, B., Schuett, M., Eklund, A. C., Ng, C., Li, Q., Hardcastle, T., Lee, A., East, P., Kschischo, M., Endesfelder, D., Wylie, P., Nyun Kim, S., Chen, J.G., Howell, M., Ried, T., Habermann, J.K., Auer, G., Brenton, J.D., Szallasi, Z., Downward, J. Chromosomal Instability Determines Taxane Response.
Proc. Nat. Acad. Sci. USA , 106 , 8671-8676 (2009).
Hasenbrink G., Kolacna L., Ludwig J., Sychrova H ., Kschischo M., Lichtenberg-Frate, H. Ring test assessment of the mKir2.1 growth based assay in Saccharomyces cerevisiae using parametric models and model-free fits.
Appl. Microbiol. Biotechnol. 73, 1212-1221 (2007).
Kschischo, M., Kern, R., Gieger, C.,Steinhauser, M. and Tolle, R.
Automatic Scoring and Quality Assessment Using Accuracy Bounds for FP-TDI SNP Genotyping Data.
Applied Bioinformatics, 4 , 75-84 (2005).
Kschischo, M., L ̈ ssig, M. and Yu, Y.-K.
Toward an Accurate Statistics of Gapped Alignments.
Bull. Math. Biol. 67, 169-191 (2005).
Rychlewski, L., Kschischo, M., Dong, L., Schutkowski, M. and Reimer, U.
Target Specificity Analysis of the Abl Kinase using Peptide Microarray Data.
J. Mol. Biol. 336, 307-311 (2004).
Schimansky-Geier, L. Kschischo, M. and Fricke, T.
Flux of Particles in Sawtooth Media.
Phys. Rev. Lett. 79 (1997).